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Fosifloxuridine nafalbenamide

CAS No. 1332837-31-6

Fosifloxuridine nafalbenamide( NUC-3373 | NUC 3373 | NUC3373 | Fosifloxuridine nafalbenamide )

Catalog No. M28004 CAS No. 1332837-31-6

NUC-3373 (Fosifloxuridine nafalbenamide), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.NUC-3373 has anticancer activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Fosifloxuridine nafalbenamide
  • Note
    Research use only, not for human use.
  • Brief Description
    NUC-3373 (Fosifloxuridine nafalbenamide), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.NUC-3373 has anticancer activity.
  • Description
    NUC-3373 (Fosifloxuridine nafalbenamide), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.NUC-3373 has anticancer activity. NUC-3373 is a ProTide transformation of 5-FU that generates much higher concentrations of FUDR-MP in patients' cells.
  • In Vitro
    Fosifloxuridine nafalbenamide induces the release of damage-associated molecular patterns (DAMPs), with increased expression of calreticulin (CRT) at the cell surface and concomitant loss of nuclear nuclear high mobility group box protein 1 (HMGB1).
  • In Vivo
    Fosifloxuridine nafalbenamide exhibits anti-cancer activity in HT-29 nude mouse xenograft models.
  • Synonyms
    NUC-3373 | NUC 3373 | NUC3373 | Fosifloxuridine nafalbenamide
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    hLigI
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1332837-31-6
  • Formula Weight
    631.55
  • Molecular Formula
    C29H30F2N4O8P
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (162.99 mM)
  • SMILES
    C[C@H](N[P](O)(=O)(OC[C@H]1O[C@@H](n2ccc(N)nc2=O)C(F)(F)[C@@H]1O)c1cccc2ccccc12)C(=O)OCc1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Howes TRL, et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017 Dec;60:29-39.
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