Fosifloxuridine nafalbenamide( NUC-3373 | NUC 3373 | NUC3373 | Fosifloxuridine nafalbenamide )

Catalog No. M28004 CAS No. 1332837-31-6

NUC-3373 (Fosifloxuridine nafalbenamide), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.NUC-3373 has anticancer activity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Fosifloxuridine nafalbenamide
Note

Research use only, not for human use.
Brief Description

NUC-3373 (Fosifloxuridine nafalbenamide), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.NUC-3373 has anticancer activity.
Description

NUC-3373 (Fosifloxuridine nafalbenamide), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.NUC-3373 has anticancer activity. NUC-3373 is a ProTide transformation of 5-FU that generates much higher concentrations of FUDR-MP in patients' cells.
In Vitro

Fosifloxuridine nafalbenamide induces the release of damage-associated molecular patterns (DAMPs), with increased expression of calreticulin (CRT) at the cell surface and concomitant loss of nuclear nuclear high mobility group box protein 1 (HMGB1).
In Vivo

Fosifloxuridine nafalbenamide exhibits anti-cancer activity in HT-29 nude mouse xenograft models.
Synonyms

NUC-3373 | NUC 3373 | NUC3373 | Fosifloxuridine nafalbenamide
Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

hLigI
Research Area

——
Indication

——

Chemical Information

CAS Number

1332837-31-6
Formula Weight

631.55
Molecular Formula

C29H30F2N4O8P
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (162.99 mM)
SMILES

C[C@H](N[P](O)(=O)(OC[C@H]1O[C@@H](n2ccc(N)nc2=O)C(F)(F)[C@@H]1O)c1cccc2ccccc12)C(=O)OCc1ccccc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Howes TRL, et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017 Dec;60:29-39.

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